| DATE | OPPONENT | LOCATION | TIME |
| 09/04/10 | at Louisville | Louisville | TBA |
| 09/11/10 | vs. Western Kentucky | Lexington | TBA |
| 09/18/10 | vs. Akron | Lexington | TBA |
| 09/25/10 | at Florida | Gainesville | TBA |
| 10/02/10 | at Ole Miss | Oxford | TBA |
| 10/09/10 | vs. Auburn | Lexington | TBA |
| 10/16/10 | vs. South Carolina | Lexington | TBA |
| 10/23/10 | vs. Georgia | Lexington | TBA |
| 10/30/10 | at Mississippi State | Starkville | TBA |
| 11/06/10 | vs. Charleston Southern | Lexington | TBA |
| 11/13/10 | vs. Vanderbilt | Lexington | TBA |
| 11/27/10 | at Tennessee | Knoxville | TBA |